Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—relapsing-remitting, secondary progressive, and primary progressive—for patient care, research, and regulatory approval of medications. Accumulating evidence suggests that the clinical course of multiple sclerosis is better considered as a continuum, with contributions from concurrent pathophysiological.. Introduction. Clinical trials in multiple sclerosis (MS) have been the cornerstone of drug development, leading to the introduction of an arsenal of disease-modifying therapies (DMT) that has provided neurologists with a range of options for the treatment of MS, thereby improving chances for a beneficial neurological outcome. 1 The ultimate goal of a curative treatment for all patients with MS.
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Several clinical trials are ongoing for progressive forms of MS, including PPMS. Read more about clinical trials for MS. In addition to treatment with a disease-modifying therapy, other symptom management and rehabilitation strategies may help people with PPMS manage the disease. Managing symptoms. Clinical trials in multiple sclerosis (MS) have led to the introduction of 15 therapeutic agents in the span of just over two decades. Prior to the modern era of these MS therapies, initial treatments of the disease during the early 20th century were empirical or experience driven and studies on potential agents were scarce and unregulated.